Methods: We utilized a generalized Q-space imaging (GQI) algorithm to analyze magnetic resonance imaging (MRI) derived from a rodent model of glioblastoma and 2 clinical datasets to correlate GQI, histology, and survival. While it is recognized that the overall resistance of glioblastoma to treatment may be related to intra-tumor patterns of structural heterogeneity, imaging methods to assess such patterns remain rudimentary. Received: OctoAccepted: JanuPublished: MaAbstract Keywords: glioma, diffusion weighted MRI, cancer biomarkers Gilbert 1ġ Chemistry and Chemical Biology, Northeastern University, Boston, MA, USAĢ Radiation Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, USAģ Department of Radiology, Brigham and Women’s Hospital, Boston, MA, USAĤ Department of Engineering Science, University of Oxford, Oxford, UKĥ Center for Theoretical and Applied Neuro-Oncology and Department of Neurosurgery, University of California, San Diego, CA, USA Mohamed 2, Nathan McDannold 3, Clifton D. Hoffman 1, Anita Mahajan 2, Abdallah S.R. Taylor 1, Yao Ding 2, Shan Zhu 1, Eric Cheah 1, Phillip Alexander 3,4, Leon Lin 1, George E.
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Google Patents Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmographyĭownload PDF Info Publication number US10631746B2 US10631746B2 US15/517,895 US201415517895A US10631746B2 US 10631746 B2 US10631746 B2 US 10631746B2 US 201415517895 A US201415517895 A US 201415517895A US 10631746 B2 US10631746 B2 US 10631746B2 Authority US United States Prior art keywords blood fluorescence fluorescence agent time tissue volume Prior art date Legal status (The legal status is an assumption and is not a legal conclusion.Erik N. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Active, expires Application number US15/517,895 Other versions US20170303800A1 #Qspace nrg pdf Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) Bailey Current Assignee (The listed assignees may be inaccurate. Original Assignee Novadaq Technologies ULC Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Application filed by Novadaq Technologies ULC filed Critical Novadaq Technologies ULC Priority to PCT/IB2014/065189 priority Critical patent/WO2016055837A1/en Assigned to NOVADAQ CORP., NOVADAQ TECHNOLOGIES INC. Assignors: MIDCAP FINANCIAL TRUST Assigned to NOVADAQ TECHNOLOGIES INC., NOVADAQ CORP. RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS).
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